Cyclic amino acid derivatives

Details Cyclic amino acid derivatives Cyclic amino acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/40 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07D 205/04 (2006.01) C07D 207/08 (2006.01) C07D 207/16 (2006.01) C07D 207/28 (2006.01) C07D 211/34 (2006.01) C07D 233/02 (2006.01) C07D 241/04 (2006.01) C07D 263/24 (2006.01) C07D 277/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2415964

Novel compounds of formula (I), wherein R1, R2, R2', R2'', R3, R4, R5, R5', R5'', R5''', R5'''', X, Y, U, V and W have the meanings given in claim no.1, are inhibitors of the coagulation factors Xa and VIIa and can be used for treating thromboses, myocardial infarct, arteriosclerosis, infections, apoplexia, angina pectoris, restenosis following angioplasty, intermittent claudication, tumors, tumor diseases and/or tumor metastases.

L'invention concerne de nouveaux composés de formule (I) dans laquelle R?1¿,R?2¿,R?2'¿,R?2''¿,R?3¿,R?4¿,R?5¿,R?5'¿,R?5''¿,R?5'''¿,R?5''''¿,X,Y,U,V et W ont la signification mentionnée dans la description. Ces nouveaux composés sont des inhibiteurs du facteur de coagulation Xa et VIIa et peuvent s'utiliser pour traiter des thromboses, l'infarctus du myocarde, l'artériosclérose, des inflammations, l'apoplexie, l'angine de poitrine, la resténose après angioplastie, la claudication intermittente, des tumeurs, des affections tumorales et/ou des métastases tumorales.

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