Modified cells and methods for inhibiting xenograft rejection

Details Modified cells and methods for inhibiting xenograft rejection Modified cells and methods for inhibiting xenograft rejection

C - Chemistry, Metallurgy

12

N

C12N 5/06 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2217131

Improved methods for inhibiting rejection of transplanted cells in allogeneic or xenogeneic recipient subject are described. The methods involve altering at least one antigen on the surface of a donor cell prior to transplantation to reduce the immunogenicity of the cell in a recipient subject. Preferably, an MHC class I antigen on a donor cell is altered by contacting the cell with a molecule which binds to the antigen, such as an antibody or fragment or derivative thereof. The altered cell can then be transplanted into a recipient subject such that immune cell-mediated, e.g., T cell-mediated, NK cell- mediated, and/or LAK cell-mediated, rejection is inhibited.

La présente invention concerne des procédés pour inhiber le rejet de cellules transplantées chez un patient receveur allogène ou xénogène. Ces procédés consistent à modifier au moins un antigène à la surface d'une cellule de donneur préalablement à la transplantation de façon à réduire l'immunogénicité de la cellule chez un patient receveur. On modifie de préférence un antigène MHC de classe I situé sur la cellule donneur, en mettant la cellule en contact avec un molécule qui se lie à l'antigène, tel qu'un anticorps, l'un de ses fragments ou l'un de ses dérivés. Il est ainsi possible de transplanter la cellule modifiée dans un sujet receveur de façon à inhiber le phénomène de rejet induit par des cellules immunitaires, notamment les lymphocytes T, les cellules NK et/ou les cellules LAK.

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