C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2397919
This invention relates to compositions and methods for inhibition of abnormal proliferation of cells or angiogenesis. More particularly this invention provides VEGF antisense oligonucleotides capable of inhibiting proliferation of cancer cells or angiogenesis or combinations thereof. Also provided are screening and prognostic assays, as well kits comprising the VEGF antisense oligonucleotides.
La présente invention concerne des compositions et des méthodes destinées à inhiber la prolifération anormale de cellules ou l'angiogenèse. La présente invention concerne, en particulier, des oligonucléotides antisens, dirigés contre le facteur de croissance de l'endothélium vasculaire (VEGF), qui sont capables d'inhiber la prolifération des cellules cancéreuses, l'angiogenèse ou des combinaisons de ces phénomènes. L'invention concerne également des analyses de détection et de pronostic, ainsi que des kits comprenant lesdits oligonucléotides antisens dirigés contre le VEGF.
Gill Parkash S.
Masood Rizwan
Gill Parkash S.
Masood Rizwan
Smart & Biggar
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