A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4045 (2006.01) A61K 31/337 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2531142
This invention relates to the use of anti-cancer agents that inhibit mitotic spindle assembly in target cells, including taxanes such as paclitaxel, and in particular to methods and means for predicting and/or reducing the resistance of cancer cells to such agents. Over-expression of aurora kinases, such as Aurora A, mediates resistance to such anti-cancer agents and the resistance of a cancer cell may be reduced by inhibiting aurora kinases and/or predicted by measuring the expression or activity of aurora kinases within the cell.
L'invention concerne l'utilisation d'agents anticancéreux inhibant l'assemblage du fuseau mitotique dans des cellules cibles, y compris les taxanes comme le paclitaxel, et en particulier des méthodes et des moyens de prévision et/ou de réduction de la résistance des cellules cancéreuses auxdits agents. La surexpression des aurora kinases, telles que l'Aurora A, sert à médier la résistance auxdits agents anticancéreux, et la résistance d'une cellule cancéreuse peut être réduite par inhibition des aurora kinases et/ou prévue par mesure de l'expression ou de l'activité des aurora kinases dans la cellule.
Anand Shubha
Venkitaraman Ashok
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cambridge University Technical Services Ltd
LandOfFree
Use of aurora kinase inhibitors for reducing the resistance... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of aurora kinase inhibitors for reducing the resistance..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of aurora kinase inhibitors for reducing the resistance... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1728594