Naturally occuring igm antibodies that bind lymphocytes

Details Naturally occuring igm antibodies that bind lymphocytes Naturally occuring igm antibodies that bind lymphocytes

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2580801

Naturally occurring IgM anti-lymphocyte autoantibodies bind to CD4 on the T lymphocytes, and downmodulate certain other receptors including CD2 on T cells and CD80 and CD86 on macrophages. Such antibodies enhance inhibition of HIV-1 from infecting cells and in addition inhibits activation and proliferation of T lymphocytes. The antibodies described herein are "naturally occurring" i.e. develop from birth in absence of deliberate immunization and secondly these antibodies are distinct from disease causing autoantibodies in that these naturally occurring antibodies are polyreactive with low binding affinity.

L'invention concerne des auto-anticorps anti-lymphocyte IgM d'origine naturelle qui se lient à CD4 sur les lymphocytes T, et modulent vers le bas certains autres récepteurs notamment CD2 sur les lymphocytes T, ainsi que CD80 et CD86 sur des macrophages. Ces anticorps améliorent l'inhibition de l'infection des cellules par le VIH-1 et inhibent en outre l'activation et la prolifération des lymphocytes T. Les anticorps décrits dans cette invention sont <= d'origine naturelle >= à savoir qu'ils se développent dès la naissance en l'absence d'immunisation délibérée, puis dans un second temps ces anticorps sont différents de la maladie produisant des auto-anticorps en ce que ces anticorps d'origine naturelle sont polyréactifs et possèdent une faible affinité de liaison.

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