A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/436 (2006.01) A61K 31/277 (2006.01) A61K 31/341 (2006.01) A61K 31/713 (2006.01) A61K 38/13 (2006.01) A61K 38/16 (2006.01) A61P 25/28 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2636692
The present invention relates to a method for treating patients having Huntington's disease by a drug increasing the phosphorylation of huntingtin at position 5 S421, thereby decreasing the polyQ-huntingtin-induced toxicity. Useful compounds are selected from the group consisting of cyclosporin A, FK506, FK520, L685,818, FK523, 15-0-DeMe- FK520, Lie120, fenvalerate, resmethrin, cypermethrin, deltamethrin. A method for selecting, identifying or screening a compound useful for treating a subject having Huntington's disease is also disclosed.
La présente invention concerne une méthode de traitement de patients atteints de la maladie de Huntington, au moyen d'un médicament qui augmente la phosphorylation de la huntingtine à la position 5 S42 et, en conséquence, diminue la toxicité induite par la polyQ-huntingtine.
Humbert Sandrine
Pardo Raul
Saudou Frederic
Centre National de La Recherche Scientifique
Fetherstonhaugh & Co.
Institut Curie
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