Use of cathepsin s in the diagnosis and treatment of...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2334117

Cathepsin S expression is up-regulated in endometriotic tissue. This invention provides methods of diagnosing endometriosis by detecting up-regulation of a cathepsin S gene product, and methods of treating endometriosis by down- regulating expression of cathepsin S in ectopic or eutopic endometriotic tissue.

Selon cette invention, l'expression de cathépsine S est régulée positivement dans un tissu endométrial. L'invention concerne des procédés pour diagnostiquer l'endométriose par la détection de la régulation positive d'un produit génique de cathépsine S ainsi que des procédés pour traiter l'endométriose par régulation négative de l'expression de cathépsine S dans des tissus ectopiques et eutopiques.

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