Combination of an allosteric carboxylic of matrix...

A - Human Necessities – 61 – K

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Details

A61K 31/519 (2006.01) A61K 31/00 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2492387

This invention provides a combination, comprising an allosteric carboxylic inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with a selective inhibitor of COX-2, or a pharmaceutically acceptable salt thereof, that is not celecoxib or valdecoxib and their use for the treatment of diseases that are responsive to inhibition of MMP.13 and cyclooxygenase-2.

L'invention concerne une combinaison comprenant un inhibiteur allostérique carboxylique de la MMP-13 ou un sel de celle-ci pharmaceutiquement acceptable avec un inhibiteur sélectif de la COX-2 ou un sel de celle-ci pharmaceutiquement acceptable qui n'est pas un Celecoxib ou un Valdecoxib; et son utilisation pour traiter des maladies sensibles à l'inhibition de la MMP-13 et de la cyclooxygénase-2.

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