Optimized anti-cd30 antibodies

Details Optimized anti-cd30 antibodies Optimized anti-cd30 antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2625998

An antibody that targets CD30, wherein the antibody comprises at least one modification relative to a parent antibody and the antibody binds with altered affinity to an FcgR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the anti-CD30 antibody.

L'invention porte sur un anticorps ciblé sur le CD30, comportant au moins une modification par rapport à un anticorps parent, se fixant avec une affinité modifiée à un FcgR, ou présentant une fonction d'effecteur modifiée par rapport à l'anticorps parent. L'invention porte également sur des méthodes d'utilisation de l'anticorps anti- CD30.

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