3-(3,5-disubstituted-4-hydroxyphenyl)propionamide...

Details 3-(3,5-disubstituted-4-hydroxyphenyl)propionamide... 3-(3,5-disubstituted-4-hydroxyphenyl)propionamide...

C - Chemistry, Metallurgy

07

D

C07D 295/02 (2006.01) A61K 31/4436 (2006.01) A61K 31/496 (2006.01) A61K 31/5375 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07C 255/24 (2006.01) C07D 277/42 (2006.01) C07D 295/033 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2498149

The present invention is directed to novel 3-(3,5-disubstituted-4- hydroxyphenyl)-propionamide derivatives that are inhibitors of Cathepsin B. Pharmaceutical composition comprising these compounds, method of treating diseases mediated by Cathepsin B, utilizing these compounds and methods of preparing these compounds are also disclosed.

L'invention concerne de nouveaux dérivés de 4-hydroxyphényl-3-3,5-disubstituté-propionamide inhibiteurs de cathepsine B. Elle concerne également une composition pharmaceutique contenant ces composés, une méthode de traitement de maladies dans lesquelles le cathepsine B joue un rôle, l'utilisation de ces composés et des méthodes servant à les préparer.

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