Screening tool for antiviral agents

Details Screening tool for antiviral agents Screening tool for antiviral agents

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2688816

A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virus units within the tumor cells and the organs of the small mammal. Specifically, the immune system of the small mammal is suppressed using cyclophosphamide. The small mammal may be, but is not limited to, one of the following: mice, rabbits, cotton rats, hamsters, rats, and other small rodents.

La présente invention concerne un procédé permettant de cribler des agents anti-adénovirus. Le procédé comprend de réduire l'activation du système immunitaire d'un petit mammifère, d'administrer un vecteur adénoviral humain au petit mammifère, de surveiller les cellules tumorales dans le mammifère, et d'analyser les unités virales infectieuses au sein des cellules tumorales et des organes du petit mammifère. Spécifiquement, le système immunitaire du petit mammifère est déprimé à l'aide de cyclophosphamide. Le petit mammifère peut être, mais sans limitation, une souris, un lapin, un rat coton, un hamster, un rat, ou tout autre petit rongeur.

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