Systems and methods for ex-vivo organ care and for using...

Details Systems and methods for ex-vivo organ care and for using... Systems and methods for ex-vivo organ care and for using...

A - Human Necessities

01

N

A01N 1/02 (2006.01)

Patent

CA 2685302

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex- vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.

L'invention concerne des systèmes, des dispositifs et des procédés se rapportant aux soins à des organes ex vivo. Dans certains modes de réalisation, l'invention concerne le maintien d'un organe ex vivo dans des états presque physiologiques. La présente invention décrit un procédé d'utilisation de la mesure de lactate dans les lignées artérielles et les tubes veineux du dispositif de perfusion cardiaque du système de soins à des organes pour évaluer: 1) le statut de perfusion global d'un cAEur isolé et 2) le statut métabolique d'un cAEur isolé et 3) la perméabilité vasculaire globale d'un cAEur de donneur isolé. Cet aspect de la présente invention utilise la propriété de l'unique capacité des cellules du myocarde à produire/générer du lactate lorsqu'elles sont privées d'oxygène et à métaboliser/utiliser le lactate pour la production d'énergie lorsqu'elles sont bien perfusées en oxygène.

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