Agent for overcoming resistance to anti-cancer agent

Details Agent for overcoming resistance to anti-cancer agent Agent for overcoming resistance to anti-cancer agent

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/426 (2006.01) A61K 31/444 (2006.01) A61K 31/4745 (2006.01) A61K 45/00 (2006.01) A61P 19/06 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 277/20 (2006.01) C07D 277/56 (2006.01) C07D 401/14 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2655895

An agent comprising, as an active ingredient, a xanthine oxidase inhibitor such as 2-[3-cyano-4-(4- fluorophenoxy)phenyl]-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-[3-cyano-4-(4-fluorophenoxy) -phenyl]thiazolo[5,4-d]pyrimidine, 2-(3-cyano-4- phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine, 2-(3- cyano-4-phenoxyphenyl)-4-hydroxythiazolo[5,4-d]pyrimidine potassium salt, 2-(3-cyano-4-phenoxyphenyl)thiazolo -[5,4-d]pyrimidine, TMX-67 and FYX-051, which can be used as an agent for overcoming the resistance to an anti-cancer agent.

L'invention concerne un agent comprenant, en tant qu'ingrédient actif, un inhibiteur de xanthine oxydase, tel que le sel de potassium de 2-[3-cyano-4-(4-fluorophénoxy)phényl]-4-hydroxythiazolo[5,4-d]pyrimidine, la 2-[3-cyano-4-(4-fluorophénoxy)-phényl]thiazolo[5,4-d]pyrimidine, la 2-(3-cyano-4-phénoxyphényl)-4-hydroxythiazolo[5,4-d]pyrimidine, le sel de potassium de 2-(3-cyano-4-phénoxyphényl)-4-hydroxythiazolo[5,4-d]pyrimidine, la 2-(3-cyano-4-phénoxyphényl)thiazolo-[5,4-d]pyrimidine, TMX-67 et FYX-051, qui peut être utilisé en tant qu'agent pour surmonter la résistance à un agent anti-cancer.

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