Methods and use of compositions comprising tnf-rii(p75)...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2328509

The present invention is directed to methods for treating asthmatic, allergic, and Th2-mediated inflammation conditions by administering a product having TNF- RII(p75) agonist properties to a human or an animal. The use of products having TNF-RII(p75) agonist properties for the preparation of pharmaceutical compositions for treating bronchial asthma, allergic and Th2-mediated inflammation conditions in humans or animals is also provided by the invention, as well as a method for screening products having TNF-RII(p75) agonist properties comprising monitoring the inhibition of pulmonary inflammation occuring in humans or animals having pulmonary inflammation.

Procédé de traitement d'états asthmatiques, allergiques et inflammatoires à médiation Th-2, qui consiste à administrer à un être humain ou à un animal un produit ayant des propriétés d'un agoniste de TNF-RII(p75). La présente invention concerne également l'utilisation de produits ayant des propriétés d'un agoniste de TNF-RII(p75) pour la préparation de compositions pharmaceutiques destinées à traiter l'asthme bronchique, les états allergiques et les états inflammatoires à médiation Th-2 chez des êtres humains ou des animaux, ainsi qu'un procédé de criblage de produits ayant des propriétés d'un agoniste de TNF-RII(p75), qui consiste à surveiller l'inhibition de l'inflammation pulmonaire chez les êtres humains et les animaux atteints d'une telle inflammation.

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