Gfats as modifiers of the p53 pathway and methods of use

Details Gfats as modifiers of the p53 pathway and methods of use Gfats as modifiers of the p53 pathway and methods of use

Category

C - Chemistry, Metallurgy

Subcategory

12

Subsubcategory

Q

IPC codes

C12Q 1/68 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Type

Patent

Patent number

CA 2449289

Description

Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.

L'invention concerne des gènes GFAT humains identifiés en tant que régulateurs de la voie p53. Ces gènes constituent des cibles thérapeutiques pour des troubles associés à un dysfonctionnement de la fonction p53. L'invention concerne des procédés d'identification de régulateur de p53, consistant à cribler des agents régulant l'activité de GFAT.

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