A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/37 (2006.01) A61K 31/70 (2006.01) A61K 31/7048 (2006.01) A61P 17/00 (2006.01)
Patent
CA 2532828
This invention relates to combinations of vasoactive substances which act at venous or arterial level with phosphodiesterase inhibitors including phosphodiesterase V, in particular: visnadin or esculoside; at least one compound selected from icarin or derivatives thereof or extracts containing it, Gingko biloba dimeric flavones either in the free form or complexed with phospholipids, amentoflavone; at least one compound selected from escin, escin beta-sitosterol complexed with phospholipids, sericoside, sericoside complexed with phospholipids or Centella asiatica extract in the free form or complexed with phospholipids. The formulations according to the invention are useful in reducing parmiculopathy and problems associated with venous insufficiency of the lower limbs.
L'invention concerne des combinaisons de substances vasoactives qui agissent au niveau veineux ou artériel avec des inhibiteurs de phosphodiestérase contenant de la phosphosdiestérase V, notamment : - de la visnadine ou de l'esculoside; - au moins un composé choisi parmi l'icarine ou des dérivés de celle-ci ou des extraits la contenant, des flavones dimériques <i>Gingko biloba</i> soit sous forme libre soit sous forme complexée avec des phospholipides, ou de l'amentoflavone; - au moins un composé choisi parmi l'escine, l'escine beta-sitostérol complexée avec des phospholipides, du séricoside, du séricoside complexé par des phospholipides ou un extrait de <i>Centella asiatica</i> sous forme libre ou complexée avec des phospholipides. Les formulations de cette invention sont utiles en vue de réduire la paniculopathie et les problèmes associés à l'insuffisance veineuse des membres inférieurs.
Indena S.p.a.
Kirby Eades Gale Baker
LandOfFree
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