A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/106 (2006.01) A61K 38/00 (2006.01) C12N 9/10 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2666859
The present invention is related to a polypeptide comprising an amino acid sequence, whereby the amino acid sequence of the polypeptide is at least 80 % identical to a stretch of consecutive amino acids of the region of HPGGT comprising an amino acid sequence corresponding to SEQ. ID.No. 1, whereby such region is defined by (a) amino acid positions 150 to 200 of the amino acid sequence according to SEQ.ID.No.l, or (b) amino acid positions 410 to 480 of the amino acid sequence according to SEQ.ID.No.l, and whereby the polypeptide is suitable to elicit an immune response which is capable of inhibiting the catalytic activity of HPGGT.
L'invention concerne un polypeptide comprenant une séquence d'acides aminés. Selon l'invention, cette séquence d'acides aminés est au moins 80 % identique à une séquence ininterrompue d'acides aminés consécutifs de la région du HPGGT qui comprend une séquence d'acides aminés correspondant à SEQ.ID.No. 1. Cette région est définie par (a) les positions d'acides aminés allant de 150 à 200 de la séquence d'acides aminés SEQ.ID.No. 1, ou (b) les positions d'acides aminés allant de 410 à 480 de la séquence d'acides aminés SEQ.ID.No. 1. En outre, le polypeptide selon l'invention peut induire une réponse immunitaire pouvant inhiber l'activité catalytique de HPGGT.
Gerhard Markus
Schmees Christian
Borden Ladner Gervais Llp
Gerhard Markus
Schmees Christian
LandOfFree
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