Pyrazole derivatives for the inhibition of cdk' s and gsk' s

Details Pyrazole derivatives for the inhibition of cdk' s and gsk' s Pyrazole derivatives for the inhibition of cdk' s and gsk' s

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A01N 43/56 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2593465

The invention provides a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein: R1 is 2,6-dichlorophenyl; R2a and R2 are both hydrogen; and R3 is a group: where R4 is C1-4 alkyl. The compounds have activity as inhibitors of CDK kinases and inhibit the proliferation of cancer cells.

La présente invention concerne un composé de formule (1), ou des sels, tautomères, solvates et N-oxydes de ceux-ci; R1 désignant 2,6-dichlorophényl; R2a et R2 représentant tous les deux hydrogène; et R3 étant un groupe où R4 est alkyle en C1-4. Les composés sont actifs en tant qu'inhibiteurs des kinases dépendantes des cyclines (CDK) et inhibent la prolifération des cellules cancéreuses.

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