A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/205 (2006.01) A61K 31/282 (2006.01) A61K 31/337 (2006.01) A61K 31/427 (2006.01) A61K 31/4745 (2006.01) A61K 31/475 (2006.01) A61K 31/513 (2006.01) A61K 31/555 (2006.01) A61K 38/14 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2740347
The present invention relates to the use of an alkanoyl L-carnitine selected from the group consisting of acetyl, propionyl, valeryl, isovaleryl and butirryl L-carnitine; in combination with one or more chemotherapeutic agent selected from the group consisting of. a camptothecin derivative; an alkylating agent; an anti- neoplastic anti-metabolite; a platin compound; a topoisomerase inhibitor; a VEGF inhibitor; a tyrosine kinase inhibitor; an EGFR kinase inhibitor; an mTOR kinase inhibitor; an insulin-like growth factor I inhibitor; a Raf kinase inhibitor; a monoclonal antibody; a proteasome inhibitor; a HDAC inhibitor; toxins; and imides; for the treatment of neoplasms.
La présente invention concerne lutilisation de L-carnitine dalcanoyle choisi parmi le groupe constitué dacétyle, de propionyle, de valéryle, disovaléryle et de L-carnitine de butyryle, en combinaison avec un ou des agents chimiothérapeutiques choisi(s) parmi le groupe constitué dun dérivé de camptothécine, dun agent dalkylation, dun anti-métabolite anti-néoplasique, dun composé de platine, dun inhibiteur de la topoisomérase, dun inhibiteur du VEGF, dun inhibiteur de la tyrosine kinase, dun inhibiteur de la kinase de lEGFR, dun inhibiteur de la mTOR kinase, dun inhibiteur du facteur de croissance insulinomimétique, dun inhibteur de Raf kinase, dun anticorps monoclonal, dun inhibiteur de protéasome, dun inhibiteur des HADC, de toxines, et dimides, pour le traitement de néoplasmes.
Carminati Paolo
Cavazza Claudio
Pisano Claudio
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.
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