G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/556 (2006.01) G01N 33/48 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2323056
The present invention relates to the study and control of atherosclerosis through the modulation of LDL-proteoglycan binding at Site B (amino acids 3359- 3369) of the apo-B100 protein in LDL. The invention encompasses methods of identifying compounds which modulate LDL-proteoglycan binding, methods of identifying compounds which modulate atherosclerotic lesion formation, and methods of modulating the formation of atherosclerotic lesions. The invention also encompasses mutant apo-B100 proteins and LDL which exhibit reduced proteoglycan binding while maintaining LDL-receptor binding, polynucleotides which encode these apo-B100 proteins, as well as cells and animals which express the mutant apo-B100 proteins.
Cette invention concerne l'étude et la régulation de l'athérosclérose par la modulation de la liaison LDL-protéoglycane au niveau du site B (acides aminés 3359-3369) de la protéine apo-B100 dans les LDL; des procédés d'identification de composés qui modulent la liaison LDL-protéoglycane, des procédés d'identification de composés qui modulent la formation de lésions athéroscléreuses et des procédés de modulation de la formation de lésions athéroscléreuses; des protéines apo-B100 mutantes et des LDL qui présentent une liaison protéoglycane réduite tout en conservant la liaison LDL-récepteur, des polynucléotides qui codent ces protéines apo-B100, ainsi que des cellules et des animaux qui expriment les protéines apo-B100 mutantes.
Boren Jan Olof Solve
Innerarity Thomas Lloyd
Regents Of The University Of California
Smart & Biggar
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