Monolithic matrix transdermal delivery system

Details Monolithic matrix transdermal delivery system Monolithic matrix transdermal delivery system

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 31/5377 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2166780

Monolithic matrix formulations for transder- mal administration of an active agent, include in combination as copolymer 2-ethylhexyl acrylate, 2-hydroxyethyl methacrylate, and methacrylic acid. Transdermal delivery devices having a monolithic matrix (4) made using such a formulation in com- bination with an active agent and a vehicle or vehi- cle formulation are capable of delivering the active agent at skin flux rates suitable for transdermal ad- ministration of the active agent.

Des formulations de matrice monolithe destinées à l'administration transdermique d'un agent actif comprennent, en combinaison, et sous forme d'un copolymère, de l'acrylate de 2-éthylhexyle, du méthacrylate de 2-hydroxyéthyle et de l'acide méthacrylique. Des dispositifs d'apport transdermique comprenant une matrice monolithe (4) produite à l'aide d'une telle formulation, en combinaison avec un principe actif et un véhicule ou une formulation de véhicule, sont capables de libérer le principe actif à des vitesses d'absorption convenant à l'administration topique de l'agent actif.

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