Treatment of pathologies which escape the immune response,...

Details Treatment of pathologies which escape the immune response,... Treatment of pathologies which escape the immune response,...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 7/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/34 (2006.01)

Patent

CA 2498383

The invention relates to the use of optimised human or humanised chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies having a strong affinity for receptor CD16 of the effector cells of the immune system and being able to induce the secretion of cytokines and interleukins, in particular 1' IFN? or 1'IL2, for the treatment of pathologies for which the target cells only express a low antigenic density and in which the effector cells can only be recruited in small quantities.

La présente invention concerne l'utilisation d'anticorps monoclonaux chimériques, humanisés ou humains optimisés qui sont produits dans des lignées cellulaires sélectionnées, lesdits anticorps présentant une forte affinité pour le récepteur CD 16 des cellules effectrices du système immunitaire mais également la propriété d'induire la sécrétion de cytokines et d'interleukines, en particulier l' IFN.gamma. ou 1'IL2 pour le traitement de pathologies pour lesquelles les cellules cibles n'expriment qu'une faible densité antigénique et dans lesquelles les cellules effectrices ne peuvent être recrutées qu'en faible quantité.

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