In vitro maturation of immature human oocytes

Details In vitro maturation of immature human oocytes In vitro maturation of immature human oocytes

C - Chemistry, Metallurgy

12

N

C12N 5/075 (2010.01) A61K 35/54 (2006.01)

Patent

CA 2477743

The invention provides methods for in vitro maturation of immature human oocytes. In one aspect, the invention provides a method for in vitro maturation of immature human oocytes, comprising the steps of: (a) inducing in a female human subject an increase in endogenous luteinizing hormone levels, said subject having not undergone an ovarian stimulation protocol prior to said inducing step; (b) obtaining from said subject an immature oocyte; and (c) culturing said oocyte until maturity.

La présente invention concerne des procédés visant à la maturation in vitro d'ovocytes humains immatures. Par un aspect, l'invention concerne un procédé visant à la maturation in vitro d'ovocytes humains immatures comprenant les étapes: (a) d'induction chez la femme d'une augmentation des niveaux d'hormone de lutéinisation endogène, cette femme n'ayant pas subi de protocole de stimulation ovarienne préalablement à l'étape d'induction; (b) de prélèvement d'ovocyte immature chez cette femme; et (c) de mise en culture de cet ovocyte jusqu'à maturité.

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