Treatment of lymphomas, leukemias, breast carcinomas,...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/45 (2006.01) A61K 31/4412 (2006.01) A61K 31/4418 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2388840

In a preferred embodiment, drugs having chemotherapeutic properties which are useful against certain neoplastic disorders with wide safety margins as evidenced by their low toxicity, and molecular actions. Such drugs include as active ingredient(s) one or more N-substituted 2-(1H) pyridone(s) and/or N- substituted 3-(1H) pyridone(s). The compositions of this invention are novel as anti-neoplastic, drugs, namely as an agent for treating leukemias, lymphomas, breast carcinomas, astrocytomas, melanomas, leiomyomas, and related tumors.

Un mode de réalisation préféré de la présente invention concerne des médicaments présentant des propriétés chimiothérapeutiques, qui sont utiles pour lutter contre certains troubles néoplasiques, avec de grandes marges de sécurité, telles que mises en évidence par leur faible toxicité, ainsi que des actions moléculaires. De tels médicaments comprennent une ou plusieurs 2-(1H) pyridone(s) N-substituée(s) et/ou 3-(1H) pyridone(s) N-substituée(s) en tant que substance(s) active(s). Les compositions selon cette invention sont nouvelles en tant que médicaments anti-néoplasiques, c'est-à-dire en tant qu'agent permettant de traiter des leucémies, des lymphomes, des carcinomes mammaires, des astrocytomes, des mélanomes, des léiomyomes et des tumeurs apparentées.

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