Epidermal growth factor receptor antagonists and methods of use

Details Epidermal growth factor receptor antagonists and methods of use Epidermal growth factor receptor antagonists and methods of use

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2575278

The present invention features epidermal growth factor receptor (EGFR) antagonists. These EGFR antagonists are polypeptide variants of ligands of EGFR. The EGFR ligand polypeptide variants of the invention possess EGFR antagonistic properties and can inhibit at least one EGFR-mediated biological activity such as inhibition of the receptor's kinase activation activity and subsequently, cell proliferation. Such polypeptide variants, and nucleic acids encoding these polypeptide variants can be used therapeutically in situations in which inhibition of EGFR activity is indicated.

L'invention porte sur des antagonistes du récepteur du facteur de croissance épidermique (EGFR), variantes de polypeptides de ligands de l'EGFR aux propriétés antagonistiques, pouvant inhiber au moins une activité biologique médiée par l'EGFR, telle que l'inhibition de l'activité d'activation de la kinase dudit récepteur, et par conséquent, la prolifération cellulaire. Ces variantes de polypeptides, et les acides nucléiques codant pour elles, peuvent être utilisées thérapeutiquement dans des situations où l'inhibition de l'activité de l'EGFR est indiquée.

Affiliated with

Also associated with

Rating

Epidermal growth factor receptor antagonists and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Epidermal growth factor receptor antagonists and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Epidermal growth factor receptor antagonists and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1733615