Npc1l1 (npc3) and methods of use thereof

Details Npc1l1 (npc3) and methods of use thereof Npc1l1 (npc3) and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12N 5/071 (2010.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/00 (2006.01) G01N 33/567 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2532576

The present invention provides human, rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.

La présente invention concerne des polypeptides NPC1L1 humains, de rat et de souris ainsi que des polynucléotides codant ces polypeptides. Cette invention concerne également des procédés de détection d'agonistes et d'antagonistes de NPC1L1. Des inhibiteurs de NPC1L1 peuvent être utilisés pour inhiber une absorption intestinale du cholestérol chez un sujet.

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