Tetrahydrofuran antifungals

Details Tetrahydrofuran antifungals Tetrahydrofuran antifungals

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 521/00 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2179396

A compound represented by formula (I) wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester (e.g., a polyestherester or phosphate ester) thereof a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

Composé de formule (I) où les X sont indépendamment tous deux F ou tous deux Cl, ou un l'un des X est indépendamment F, et l'autre indépendamment Cl; R1 est un groupe alkyle (C3 à C8) à chaîne droite ou ramifiée substitué par une ou deux fractions hydroxy, ou l'un de ses éther ou ester (p. ex. un poly (éther-ester) ou un ester phosphorique) ou l'un de ses sels pharmacocompatibles, ou une préparation pharmaceutique le contenant, servant au traitement ou à la prévention des mycoses.

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