Human amine receptor

Details Human amine receptor Human amine receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224094

A human amine receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for detecting compounds which bind to and activate and bind to and inhibit such polypeptide and the use of compounds for treating diseases related to the underexpression and overexpression of the human amine receptor of the present invention. Also disclosed are methods for detecting mutations in the nucleic acid sequence encoding the polypeptide and for detecting altered levels of the soluble form of the polypeptide.

La présente invention concerne un polypeptide récepteur d'amines humaines et l'ADN (ARN) codant ce polypeptide, ainsi qu'un procédé de production dudit polypeptide par techniques de recombinaison. Elle concerne également des procédés de détection de composés liant et activant ou liant et inhibant ce polypeptide et l'utilisation de ces composés dans le traitement de maladies liées à la sous-expression ou à la surexpression du récepteur d'amines humaines décrit. Linvention a en outre pour objet des procédés permettant de détecter des mutations dans la séquence d'acide nucléique codant le polypeptide, ou encore des modifications de la concentration de la forme soluble du polypeptide.

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