C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2391433
The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an aminoacylation domain. The catalytic RNA molecules having trans aminoacylation activity only have the catalytic domain. A method is provided for constructing and screening of these molecules. These molecules are suitable for aminoacylating tRNA-like molecules with specific amino acids.
La présente invention concerne des molécules d'ARN catalytique à activité d'aminoacylation cis ou trans. Les molécules d'ARN catalytique à activité d'aminoacylation cis comprennent un domaine catalytique et un domaine d'aminoacylation. Les molécules d'ARN catalytique à activité d'aminoacylation trans ne comprennent que le domaine catalytique. L'invention concerne également une méthode de construction et de criblage de ces molécules. Ces molécules sont adaptées pour aminoacyler des molécules de type ARNt avec des acides aminés spécifiques.
Bonzagni Neil
Dimitrios Kourouklis
Hiroaki Suga
Hirohide Saito
Lee Nick
Gowan Intellectual Property
The Research Foundation Of State University Of New York
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