Substituted 1,3-oxathiolanes with antiviral properties

Details Substituted 1,3-oxathiolanes with antiviral properties Substituted 1,3-oxathiolanes with antiviral properties

C - Chemistry, Metallurgy

07

D

C07D 411/04 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2188283

This invention relates to single enantiomers of novel cis-substituted 1,3- oxathiolanes, of formula (I) wherein R1 is hydrogen, and R2 is cytosine or 5- fluorocytosine, and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.

L'invention concerne des énantiomères individuels propres à de nouveaux 1,3-oxathiolanes substitués en cis de formule (I) dans laquelle R¿1? représente hydrogène, et R¿2? cytosine ou 5-fluorocytosine, ainsi que leurs sels et esters acceptables sur le plan pharmacologique. Elle concerne aussi des compositions pharmaceutiques les contenant et l'utilisation de ces composés comme agents antiviraux, notamment dans des thérapies combinées.

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