Stabilised virus preparation

Details Stabilised virus preparation Stabilised virus preparation

A - Human Necessities

61

K

A61K 35/76 (2006.01) A61K 39/12 (2006.01) A61K 39/245 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2329000

Stabilised dried pharmaceutical compositions dispersible in aqueous liquid for injection comprise (i) virus e.g. for use as a vaccine or vector, preferably a herpesvirus, e.g. attenuated or genetically disabled infectious herpes simplex virus or varicella zoster virus, (ii) polysaccharide, e.g. dextran, and/or a source of mixed aminoacids of vegetable or bacterial origin, (iii) a buffer, and (iv) a mono- or oligo-saccharide or derivative thereof.

L'invention concerne des compositions pharmaceutiques stabilisées séchées, dispersables dans un liquide aqueux et destinées à l'injection. Elles comprennent (i) un virus, du type de ceux utilisés en tant que vaccins ou vecteurs, de préférence un virus de l'herpès tel qu'un virus infectieux herpès simplex ou varicelle-zona atténué ou génétiquement désactivé, (ii) un polysaccharide, p.ex. dextrane, et/ou une source d'acides aminés mixtes d'origine végétale ou bactérienne, (iii) un tampon et (iv) un mono- ou oligosaccharide ou un dérivé correspondant.

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