Screen for pre-eclampsia

G - Physics – 01 – N

Patent

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G01N 33/68 (2006.01)

Patent

CA 2522285

It has been demonstrated that the level of asymmetric dimethylarginine (ADMA) increases in women that subsequently develop pre-eclampsia or whose fetus subsequently develops intrauterine growth restriction (IUGR) and that ADMA plays a key role in the development of maternal hypertension. Accordingly, the level of ADMA in a pregnant woman can be used to determine whether or not a pregnant woman is at risk of developing pre-eclampsia or whether or not a fetus is at risk of developing IUGR. Furthermore, antagonists of ADMA activity are useful in the inhibition or prevention of pre-eclampsia or inhibition or prevention of IUGR.

Il a été démontré que le taux de diméthylarginine asymétrique (ADMA) augmente chez des femmes développant par la suite une pré-éclampsie ou dont le foetus développe par la suite un retard de croissance intra-utérin (IUGR) et que la ADMA joue un rôle clef dans le développement de l'hypertension maternelle. Par conséquent, le taux de ADMA chez une femme enceinte peut être utilisé pour déterminer si celle-ci présente un risque de développer une pré-éclampsie ou si le foetus présente un risque de développer un IUGR. De plus, des antagonistes de l'activité de la ADMA sont utiles pour l'inhibition ou la prévention de la pré-éclampsie ou l'inhibition ou la prévention du IUGR.

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