Serine hydrolase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/04 (2006.01) A61K 31/536 (2006.01) A61P 29/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2664152

Provided herein are benzoxazinone compounds of formula (I) and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.

L'invention concerne des composés de benzoxaninone de formule (I) et des compositions renfermant ces composés. Ces composés et compositions sont utiles dans les méthodes d'inhibition de l'action de la sérine hydrolase, y compris de l'élastase neutrophile. Dans certains modes de réalisation, les composés et les compositions sont utiles dans la prévention, l'amélioration ou le traitement de maladies véhiculées par la sérine hydrolase.

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