Thiazole-derivatives

Details Thiazole-derivatives Thiazole-derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/48 (2006.01) A61K 31/427 (2006.01)

Patent

CA 2347741

Compounds of formula (I) as well as pharmaceutically usable salts and esters thereof, wherein R1 is (see formula III or IV or V); R2 is (see formula II) R3 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, carboxy, alkyl-O- CO- or aralkyl-O-CO; R4 is hydrogen, alkyl, cycloalkyl or aryl; R5, R6, R and R8 are hydrogen; R9 is hydrogen, alkyl or cycloalkyl; A is oxygen, sulphur, -CH=CH- or (see formula VI); R10 is hydrogen, aryl, aralkyl, carboxyalkyl, alkyl, cycloalkyl, alkyl-O-CO-, aralkyl-O- CO-, alkyl-CO-, alkylsulphonyl or aryl-sulphonyl; inhibit the binding of adhesive proteins to the surface of different types of cell and accordingly influence cell-cell and cell-matrix interactions. They can be used in the form of pharmaceutical preparations in the control or prevention of neoplasms, tumour metastasizing, tumour growth, osteoporosis, Paget's disease, diabetic retinopathy, macular degeneration, restenosis following vascular intervention, psoriasis, arthritis, fibrosis, kidney failure as well as infections caused by viruses, bacteria or fungi.

L'invention porte sur des composés de formule (I), où R<1>, R<2> et R<3> ont la signification donnée dans la revendication 1, et sur leurs sels et esters pharmacocompatibles. Lesdits composés empêchent la fixation de protéines adhérentes à la surface de différents types de cellules et influent de ce fait les interactions cellule-cellules et cellule-matrice. Ils peuvent servir sous forme de préparations pharmaceutiques à limiter ou prévenir les néoplasmes, l'évolution vers des métastases de tumeurs, la croissance des tumeurs, l'ostéoporose, la maladie de Paget, la rétinopathie diabétique, la dégénérescence maculaire, les resténoses consécutives à une intervention vasculaire, le psoriasis, les fibroses, l'insuffisance rénale, ainsi que des infections virales, bactériennes ou mycosiques.

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