New disubstituted phenylpyrrolidines as modulators of...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/08 (2006.01) A61K 31/40 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2689692

The present invention provides compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically to the use of 3-(disubstituted aryl)-pyrrolidines for the treatment of central nervous system disorders.

La présente invention concerne des composés qui augmentent les taux extracellulaires de catécholamines, la dopamine et la norépinéphrine, dans les zones corticales cérébrales du cerveau des mammifères, et plus particulièrement l'utilisation de 3-(aryl disubstitué)-pyrrolidines pour le traitement des troubles du système nerveux central.

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