Corneal opacification inhibitory composition

Details Corneal opacification inhibitory composition Corneal opacification inhibitory composition

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61F 9/00 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) A61K 31/38 (2006.01)

Patent

CA 2171057

An ophthalmic preparation which comprises a fumagillol derivative represented by the general formula(I): Image (I) wherein R1 is hydrogen; R2 is a halogen, N(O)mR5R6, N+R5R6R7 X-, S(O)nR5 or S+R5R6 X-, wherein R5, R6 and R7 represent independently a substituted or unsubstituted hydrocarbon group or a substituted or unsubstituted heterocyclic group; X- represents a counter anion; m represents 0 or 1; n represents an integer from 0 to 2; or R5 and R6 together with the adjacent nitrogen or sulfur atom may form a substituted or unsubstituted nitrogen- or sulfur-containing heterocyclic group which may form a condensed ring ; or R1 and R2 are combined to represent a chemical bond; R3 is a substituted or unsubstituted 2-methyl-1-propenyl group or a substituted or unsubstituted isobutyl group; A is oxygen or NR8, wherein R8 represents hydrogen, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted aryl group ; and R4 is hydrogen, a substituted or unsubstituted hydrocarbon group or a substituted or unsubstituted acyl group and a salt thereof is useful for inhibiting corneal opacification occurring after ophthalmic surgery.

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