Methods for inducing a sustained immune response against a...

Details Methods for inducing a sustained immune response against a... Methods for inducing a sustained immune response against a...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2739918

The present invention relates to methods of inducing and maintaining an immune response against a B-cell idiotype in a subject using an autologous anti-idiotypic vaccine. In one embodiment, the immune response is induced and maintained for treatment of a B-cell derived malignancy selected from among non- IIodgkin's lymphoma, HodgkiiTs lymphoma, chronic lymphocytic leukemia, multiple myeloma, and mantle cell lymphoma.

La présente invention concerne des procédés d'induction et de maintien d'une réponse immunitaire contre un idiotype de cellules B chez un sujet, au moyen d'un vaccin autologue anti-idiotypique. Dans un mode de réalisation, la réponse immunitaire est induite et maintenue pour le traitement d'une néoplasie dérivée des cellules B choisies parmi un lymphome non Hodgkinien, un lymphome de Hodgkin, une leucémie lymphocytaire chronique, un myélome multiple et un lymphome du manteau.

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