Use of indomethacin and derivatives as broad-spectrum...

A - Human Necessities – 61 – K

Patent

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A61K 31/405 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2535448

Object of the present invention is the use of indomethacin (INDO) and its derivatives and salts as antiviral drugs, since it was found that INDO is able to stimulate an antiviral defense response in cells attacked by viruses. This antiviral response has been found in the presence of INDO alone and/or in combination with other compounds, for instance with metals and metal- containing compounds, Prostanoids and antiviral drugs. In combination with these compounds INDO develops an unexpected as well as effective synergic antiviral action.

L'invention concerne l'utilisation d'indométhacine (INDO) et de ses dérivés et des ses sels en tant que médicaments antiviraux, étant donné qu'on a découvert que INDO est capable de stimuler une réponse antivirale de défense dans des cellules attaquées par des virus. Cette réponse antivirale a été découverte en présence de INDO seule et/ou combinée à d'autres composés, par exemple, des métaux et des composés contenant des métaux, des prostanoïdes et des médicaments antiviraux. Combinée à ces composés, INDO exerce une action antivirale synergique inattendue et efficace.

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