C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/235, 260/304
C07D 263/30 (2006.01) A61K 31/42 (2006.01) C07D 263/32 (2006.01) C07D 263/46 (2006.01) C07D 413/02 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2032674
ABSTRACT Oxazole derviatives having Formula I or II are disclosed which are useful as inhibitors of mammalian blood platelet aggregation. Image Image (I) (XIX) Image Image (II) (XX) Formula I and Formula XIX compounds are those wherein n is 7-9 and R is hydrogen or lower alkyl. Formula II compounds are those wherein R is hydrogen, lower alkyl or together with CO2 is tetrazol-1-yl; R1 is phenyl or thienyl; X is a divalent connecting group selected from the group consisting of CH2CH2, CH=CH, and CH2O; Y is a divalent connecting group attached to the 3 or 4 phenyl position selected from the group consisting of OCH2, CH2CH2 and CH=CH. Formula XX compounds are those wherein the OCH2CO2R moiety is attached to the 3 or 4 phenyl position and R is hydrogen or lower alkyl.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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