A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/04 (2006.01)
Patent
CA 2115794
ABSTRACT OF THE DISCLOSURE Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula: Image (I) [wherein Z is H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R is C1-C25 alkyl, cycloalkyl, or halo-lower-alkyl, each optionally substituted with halo, fluoro-lower-alkyl, aryl, lower- alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy- carbonyloxy, or R is a group of the formula: Image -(CR1R2)p - (CR3 = CR4)mQ, or -(CR1R2)p - C ? C - Q; R1, R2, R3 and R4 are independently H, lower-alkyl, optionally substituted with halo; Z', independently from Z, has the same meaning given to Z; x and x' are each 1-4; n and n' are each 1-4; is 1-15; p is 1-20; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl] and methods for their use in diagnostic radiology of the gastrointestinal tract.
Bacon Edward R.
Caulfield Thomas J.
Douty Brent D.
Illig Carl R.
Josef Kurt A.
Fetherstonhaugh & Co.
Sterling Winthrop Inc.
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