Treatment of infection due to clostridium difficile

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/53 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 16/40 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2519821

The present invention discloses a Clostridium difficile lactate dehydrogenase comprising the amino acid sequence of SEQ ID NO: 2, or an amino acid sequence exhibiting at least 70, 80, 90, 95, 96, 97, 98, 99, or 99.5% identity with the amino acid sequence of SEQ ID NO: 2. A Clostridium difficile lactate dehydrogenase comprising the amino acid sequence of SEQ ID NO: 2. Also disclosed are nucleic acid sequences encoding same, vectors and host cells, antibodies against same, medicaments and methods of manufacture of a medicament for the treatment of a Clostridium difficile infection, and diagnostic test kits and diagnostic test methods for same.

L'invention concerne une lactate déshydrogénase de Clostridium difficile contenant la séquence d'acides aminés de SEQ ID NO: 2, ou une séquence d'acides aminés présentant au moins 70, 80, 90, 95, 96, 97, 98, 99 ou 99,5 % d'identité avec la séquence d'acides aminés de SEQ ID NO: 2. L'invention concerne également une lactate déshydrogénase de Clostridium difficile contenant la séquence d'acides aminés de SEQ ID NO: 2. L'invention concerne encore des séquences d'acides nucléiques la codant, des vecteurs et des cellules hôtes, des anticorps, des médicaments et des procédés de fabrication d'un médicament destiné à traiter une infection à Clostridium difficile, ainsi que des kits de tests diagnostiques et des méthodes de tests diagnostiques.

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