C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/60 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/198 (2006.01) A61K 31/22 (2006.01) A61K 31/221 (2006.01) A61K 31/223 (2006.01) A61K 31/341 (2006.01) A61K 31/357 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 31/4035 (2006.01) A61K 31/4045 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/4166 (2006.01) A61K 31/4184 (2006.01) A61K 31/426 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A6
Patent
CA 2329704
A class of substituted .beta.-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
L'invention concerne une catégorie de .beta.-amino-acides substitués, lesquels constituent des inhibiteurs puissants de la méthionine aminopeptidase de type 2 (MetAP2) et sont donc utiles pour inhiber l'angiogénie et des pathologies qui dépendent de l'angiogénie pour leur développement, comme la rétinopathie diabétique, la croissance tumorale et des états inflammatoires. L'invention concerne également des préparations pharmaceutiques contenant ces composés, ainsi que des procédés d'inhibition de la méthionine aminopeptidase-2 et de l'angiogénie.
Craig Richard A.
Henkin Jack
Kawai Megumi
Lynch Linda Lijewski
Patel Jyoti
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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