C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/02 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 209/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2395867
The present invention relates to a novel class of substituted phenylpiperazinyl derivatives having the formula (I) wherein X, Z, Y, U,V, Alk, W, R1 , R2, R3, R11, R12, R13 n, m and the dotted line are as defined in the description. The compounds of the invention are dopamine D4 receptor ligands and are therefore useful for the treatment of certain psychiatric and neurologic disorders, including psychosis.
La présente invention concerne une nouvelle classe de dérivés de phénylpipérazinyle substitué représentés par la formule (I) dans laquelle X, Z, Y, U, V, Alk, W, R?1¿, R?2¿, R?3¿, R?11¿, R?12¿, R?13¿ n, m et la ligne en pointillé sont tels que définis dans le descriptif. Les composés de l'invention sont des ligands du récepteur de la dopamine D4 et sont par conséquent utilisés dans le traitement de certains troubles psychiques et neurologiques, notamment la psychose.
Andersen Kim
Bang-Andersen Benny
Kehler Jan
Rottlander Mario
Ruhland Thomas
H. Lundbeck A/s
Robic
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