Pyrazole derivatives having tyrosine kinase activity

Details Pyrazole derivatives having tyrosine kinase activity Pyrazole derivatives having tyrosine kinase activity

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 491/14 (2006.01)

Patent

CA 2618524

The invention relates to the compounds of formula (I), wherein R, X, R1, R2, R3 and R4 are defined as in claim 1. The inventive compounds are tyrosinkinase, especially TIE-2, and Raf kinase inhibitors and can inter alia be used in the treatment of tumors.

L'invention concerne des composés de formule (I), dans laquelle R, X, R1, R2, R3 et R4 ont les significations indiquées dans la revendication (1). Ces composés sont des inhibiteurs des tyrosine kinases, en particulier TIE-2, et des kinases Raf et ils peuvent être utilisés pour traiter des tumeurs.

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