C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/429 (2006.01) A61P 39/00 (2006.01) C07D 209/00 (2006.01) C07D 279/00 (2006.01)
Patent
CA 2361580
Thiazole-indole compounds useful as cyclin dependent kinase II inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiation therapy in a patient receiving such therapy.
La présente invention concerne des composés thiazolo-indoliques convenant comme inhibiteurs de la kinase dépendante des cyclines de type II. Ces composés permettent de prévenir ou de réduire la gravité des effets secondaires de cytotoxicité épithéliale (alopécie, syndrome plantaire-palmaire, inflammation de muqueuse, etc.) induits par une chimiothérapie et/ou une radiothérapie chez patient suivant un tel traitement.
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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