Method of inducing embryonic stem cells into pancreatic cells

Details Method of inducing embryonic stem cells into pancreatic cells Method of inducing embryonic stem cells into pancreatic cells

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/0735 (2010.01)

Patent

CA 2604189

The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.

La présente invention concerne une approche simple en trois temps reposant sur l'induction combinatoire à l'activine A de l'acide tout-trans rétinoïque, et éventuellement d'autres facteurs de maturation capables d'induire la différentiation de cellules souches embryonnaires en cellules productrices d'insuline. L'invention concerne également un nécessaire servant à l'induction de la différentiation des cellules souches embryonnaires en cellules productrices d'insuline.

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