Reduction products of rapamycin

Details Reduction products of rapamycin Reduction products of rapamycin

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) C07D 498/18 (2006.01)

Patent

CA 2067541

Reduction of rapamycin with DIBAL furnishes either the 15-hydroxyrapamycin or 15,27-bis(hydroxy)rapamycin, depending upon the reaction conditions, having the general structure (see formula I) where Y is -CO- or -CH(OH)-. The compounds of this invention are useful in treating transplant rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, and fungal infections.

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