Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

167/231, 260/272

C07D 453/02 (2006.01) A61K 31/435 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2038908

26474-222 ABSTRACT 3-(3-Indolyl)quinuclidines of the formula I Ind-R I in which Ind is a 3-indolyl group which is unsubstituted or monosubstituted to tetrasubstituted by 1-4-C-alkyl, trifluoro- methyl, 1-4-C-alkoxy, 1-4-C-alkylthio, fluorine, chlorine, hydroxyl, hydroxymethyl, 6-10-C-aryloxy, 7-11-C-aralkyloxy, 1-5-C-acyloxy, 6-10-C-aroyloxy, 1-4-C-alkylsulfonyloxy, 6-10-C- arylsulfonyloxy, carboxyl, 1-4-C-alkoxycarhonyl and/or methylene- dioxy and R is 3-quinuclidinyl or 2,3-dehydro-3-quinuclidinyl, and their physiologically acceptable salts can be used as psychopharmaceuticals. The compounds are especially useful in the treatment of disorders characterized by an excess of circulating serotonin or by a serotonergic hyperactivity.

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