Medicinal combination useful for in vivo exogenic...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/70 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2211039

This invention involves a drug association of at least one immunosuppressant agent and at least one recombinant adenovirus with a genome including a first recombinant DNA containing a therapeutic gene and a second recombinant DNA containing an immunoprotective gene, for consecutive, intermittent and/or simultaneous use in time, useful for in vivo and/or ex vivo exogenic transfection.

La présente invention concerne une association médicamenteuse d'au moins un agent immunosuppresseur et d'au moins un adénovirus recombinant dont le génome comprend une premier ADN recombinant contenant un gène thérapeutique et un second ADN recombinant contenant un gène immunoproctecteur, pour une utilisation consécutive, intermittente et/ou simultanée dans le temps, utile pour des transfections exogéniques in vivo et/ou ex-vivo.

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