Methods to increase white blood cell survival after...

A - Human Necessities – 61 – K

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Details

A61K 38/08 (2006.01) C07K 5/093 (2006.01) C07K 5/097 (2006.01) C07K 5/103 (2006.01) C07K 5/113 (2006.01) C07K 7/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2322963

The present invention provides improved methods, kits, and pharmaceutical compositions for increasing white blood cell survival following chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of angiotensinosin, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, All fragments or analogues thereof or AII AT2 type 2 receptor agonists.

La présente invention concerne des méthodes améliorées, des nécessaires d'analyses, et des compositions pharmaceutiques destinés à augmenter le taux de survie des globules blancs après une chimiothérapie, et à mobiliser et à faire circuler, à partir de la moelle osseuse, des cellules souches hématopoïétiques dans le sang périphérique, qui comprennent l'administration d'une quantité suffisante d'angiotensinogène, d'angiotensine I (AI), d'analogues d'AI, de fragments d'AI et de leurs analogues, d'angiotensine II (AII), d'analogues d'AII, de fragments d'AII ou de leurs analogues ou d'agonistes du récepteur AT2 de type 2 de AII.

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